Description of the video:
Jamie Renbarger: We saw Tyler at the time of his initial relapse of his osteosarcoma in May of 2017. We saw him as part of the Precision Genomics Program, and through that clinical consult, we did clinical sequencing, as well as research based sequencing, of his tumor as well as of his own DNA from his blood to try to understand what was driving his tumor to grow at that time.
Jamie Renbarger: That facilitated our selecting four medications, traditional cytotoxic chemotherapy really in combination with novel, small molecule, targeted inhibitors that we felt together in combination would be safe and potentially effective at either stopping or slowing down tumor growth.
Tyler Trent: Yeah, I know. I tell people that without the research that's been done I wouldn't be here. I wouldn't be able to speak to you. I know because the genomic testing that was done on my tumor, you know those drugs that were found basically prolonged my life.
Jamie Renbarger: So one of the challenges that we face in pediatrics is that the number of tumor models, particularly from relapsed, solid tumors, are very few, few and far between, and in order for us to have laboratory models to study, not just upfront cancer but specifically the bad actors that come back, we have to have models in the lab to able to study those.
Jamie Renbarger: And so, again, one of the really amazing things and very unique things about the samples and models that we were able to collect and develop from Tyler is that we not only have a sample from the time of his relapse prior to relapse chemotherapy, but also from after he got chemotherapy. So we can understand what we call the tumor adaptive response, how it changes after exposure to chemotherapy, and also have both of those models to study in the laboratory.
Tyler Trent: As people continue to be diagnosed, that will prolong other kids lives as well. And hopefully because of that, that those kids will basically become advocates for research. That they would be able to prolong other kids lives and that they become a snowball effect. And that we’d be able to prolong hundreds of thousands of kids lives.